COMPOSITION
Levamisole hydrochloride (corresponding to 2.542 g of Levamisole) ……. …………….…. 3.00g
Oxyclozanide …… .. …………………………. ………………………………………… .... 6.00g
Excipient qsp ……………………………………………………………… .. ……… ....... 100ml
PHARMACEUTICAL PROPERTIES
Levamisole is an anthelmintic from the imidazothiazole family with
of great activity on larval and adult forms of gastrointestinal strongyles and
pulmonary. The mode of action of Levamisole is linked to muscle paralysis of the
parasites. Levamisole is well absorbed by the oral route, it diffuses well in all tissues that
which allows it to reach pulmonary nematodes and hypobiosis forms.
Levamisole is endowed with non-specific immunostimulatory effects.
Levamisole is rapidly metabolized by the liver and eliminated via the urinary and biliary tract
hence its relatively short waiting period.
Oxyclozanide, an anthelmintic in the salicylanilide family, is gifted
of a broader spectrum that includes trematodes, blood-sucking nematodes, larvae
hypoderma and Oestrus spp. However, despite its age, Oxyclozanide has
the advantage of being the most active product on paramphistomum spp as well as adults
than larval.
Its action is exerted on both adult and immature forms by a decoupling effect
oxidative phosphorylation in the trematode. Pharmacologically,
Oxyclozanide is characterized by a relatively long half-life (long
persistence) attributed in part by its strong binding to plasma proteins (99%).
The two products, Levamisole and Oxyclozanide, although persistent
different, are characterized by a great therapeutic complementarity.
TARGET SPECIES
Sheep, Goats, Cattle.
INDICATIONS
Prophylaxis and treatment in cattle, sheep and goats of the following infestations:
- Gastrointestinal and pulmonary strongylosis;
- Fascilose (large fluke);
- Teniasis (elimination of segments).
ADMINISTRATION AND DOSAGE
ATLAZANIDE is recommended as a single oral dose at a dosage of 2.5 ml / 10
kg of body weight, corresponding to 7.5 mg of Levamisole and 15 mg of Oxyclozanide per
kilogram of live weight
CONTRAINDICATIONS AND INTERACTIONS
* Administration to animals suffering from reduced hepatic functions.
* Simultaneous administration with organic pyrantel, morantel or phosphate.
* Administration to dairy females producing fluid milk, lactating or
in a dry period or among future drinking milk producers in the
two months before giving birth.
* Do not use in equines
SIDE EFFECTS
If the general conditions of use are respected and if the recommended doses are
observed, no side effects were observed in the target species.
PRECAUTIONS FOR USE
- Respect the recommended dosage.
- Shake well before use.
- Use with caution in goats
TIMEOUT
Meat and offal: 14 days
Milk: see contraindications
STORAGE CONDITIONS
- 2 years in the original packaging, protected from light and at a temperature below
25 ° C.
- Stability after opening the container: 3 Weeks
PRESENTATIONS:
250 ml bottles; 500 ml and 1L.
