Composition:
Each 1 ml contains:
metronidazole: 5 mg
Properties:
Metronidazole is a synthetic, nitroimidazole antibacterial and antiprotozoal agent.
Metronidazole is bactericidal against
susceptible bacteria. Its antimicrobial activity is disrupting DNA and nucleic acid synthesis in the bacteria. Metronidazole has
activity against most obligate anaerobes including Bacteroides sp. (including B. fragilis), Fusobacterium, Veillonella, Clostridium
sp., Peptococcus, and Peptostreptococcus.
Metronidazole is also trichomonacidal and amebicidal in action and acts as a direct
amebicide. Its mechanism of action for its antiprotozoal activity is not understood.
It has therapeutic activity against Entamoeba
histolytica, Trichomonas, Giardia, and Balantidium coli.
Metronidazole is relatively well absorbed after oral administration.
Metronidazole is rather lipophilic and is rapidly and widely distributed after absorption.
It is distributed to most body tissues and
fluids.
Indications:
Horses:
" Pleuropneumonia and lung abscesses caused by anaerobic penicillin-resistant Bacteroides fragilis and clostridial enterocolitis.
Cats and dogs:
In small animals
" Bacterial stomatitis, osteomyelitis, hepatitis, pneumonia, lung abscessation, anaerobic clostridial enteritis, and peritonitis.
" Giardiasis and other protozoal infections caused by Trichomonas, Balantidium coli.
Target species:
Horses, dogs and cats.
Dosage & Administration:
For horses:
by intravenous, subcutaneous administration.
Dose of product:
4 ml / kg b.wt, twice daily for 5-7 days.
For dogs & cats:
by intravenous, subcutaneous administration.
Dose of product:
4 ml / kg b.wt, twice daily for 5-7 days.
Contraindications:
-Metronidazole is contraindicated in animals hypersensitive to the drug or nitroimidazole derivatives.
-It has also been recommended not to use the drug in severely debilitated, pregnant or nursing animals.
-Metronidazole should be used with caution in animals with hepatic dysfunction.
Adverse Effects / Warnings:
Adverse effects reported in dogs include neurologic disorders, lethargy, weakness, neutropenias, hepatotoxicity, hematuria,
anorexia, nausea, vomiting and diarrhea.
Neurologic toxicity may be manifested after acute high dosages or, more likely, with chronic moderate to high-dose therapy.
Withdrawal time:
Not to be used in horses that may be slaughtered for human consumption.
Storage:
Store at a temperature not exceeding 30°C away from light and to be used during 3 months after opening at
temperature not exceeding 30°C away from light.
